Chlorogenic acid health benefit

Chlorogenic acid is a common dietary polyphenol found in many plants including certain fruits, green tea and green coffee bean. Chlorogenic acids are major secondary metabolites found in coffee seeds. Chlorogenic acid has a metabolite called m-coumaric acid.

Chlorogenic acid in green coffee
Chlorogenic acids from green coffee extract are highly bioavailable in humans.
J Nutr. 2008 Dec; Farah A, Monteiro M, Donangelo CM, Lafay S. Departamento de Bioquímica, Laboratório de Bioquímica Nutricional e de Alimentos, Instituto de Química, Universidade Federal do Rio de Janeiro, Ilha do Fundão, RJ, Brazil.
Chlorogenic acids are cinnamic acid derivatives with biological effects mostly related to their antioxidant and antiinflammatory activities. Caffeoylquinic acids (CQA) and dicaffeoylquinic acids (diCQA) are the main Chlorogenic acids found in nature. Because green coffee is a major source of Chlorogenic acids, it has been used for production of nutraceuticals. Our study shows that the major Chlorogenic acids compounds present in green coffee are highly absorbed and metabolized in humans.

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Chlorogenic acid for weight loss
The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.
J Int Med Res. 2007 Nov-Dec. Thom E. ETC Research and Development, Oslo, Norway.
The results from a clinical study performed in 12 healthy volunteers with different coffee products containing glucose show that instant coffee enriched with chlorogenic acid induced a reduction in the absorption of glucose of 6.9% compared with control. No such effects were seen with normal or decaffeinated instant coffee. In a second, comparative, randomized, double-blind, 12-week study we investigated the effect on the body mass of 30 overweight people, compared with normal instant coffee. The average losses in mass in the chlorogenic acid enriched and normal instant coffee groups were 5.4 and 1.7 kg, respectively. We conclude that chlorogenic acid enriched instant coffee appears to have a significant effect on the absorption and utilization of glucose from the diet. This effect, if the coffee is used for an extended time, may result in reduced body mass and body fat when compared with the use of normal instant coffee.

Chlorogenic acid protects against radiation
Radioprotective effects of chlorogenic acid against mortality induced by g-irradiation in mice.
Methods Find Exp Clin Pharmacol. 2008 Jan-Feb. Hosseinimehr SJ, Zakaryaee V, Ahmadi A, Akhlaghpoor S. Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
The radioprotective effects of the naturally occurring compound chlorogenic acid have been investigated against mortality induced by gamma-irradiation in mice. Chlorogenic acid was administrated at single doses of 100, 200 and 400 mg/kg 1 or 24 h prior to lethal dose of gamma-irradiation (8.5 Gy). Chlorogenic acid exhibited concentration-dependent activity on 1,1-diphenyl-2-picrylhydrazyl free radical to show strong antioxidant activity. It appeared that chlorogenic acid with antioxidant activity reduced mortality induced by gamma-irradiation.

Chlorogenic acid raw herb and material suppliers
Chlorogenic acid is sold at 20 percent, 30 percent and 98 percent concentration.

Chemistry
Chlorogenic acid is the ester formed between certain trans cinnamic acid and (L)-quinic acid.