Chlorogenic acid health benefit

Chlorogenic acid is a common dietary polyphenol found in many plants including certain fruits, green tea and green coffee bean. Chlorogenic acids are major secondary metabolites found in coffee seeds. Chlorogenic acid has a metabolite called m-coumaric acid.

Chlorogenic acid in green coffee
Chlorogenic acids from green coffee extract are highly bioavailable in humans.
J Nutr. 2008; Farah A, Monteiro M, Donangelo CM. Departamento de Bioquímica, Laboratório de Bioquímica Nutricional e de Alimentos, Instituto de Química, Universidade Federal do Rio de Janeiro, Ilha do Fundão, RJ, Brazil.
Chlorogenic acids are cinnamic acid derivatives with biological effects mostly related to their antioxidant and antiinflammatory activities. Caffeoylquinic acids (CQA) and dicaffeoylquinic acids (diCQA) are the main ones found in nature. Because green coffee is a major source of chlorogenic acids, it has been used for production of nutraceuticals. Our study shows that the major chlorogenic acids compounds present in green coffee are highly absorbed and metabolized in humans.

Green Tea Extract, 100 mg pill

Green tea extract  offers a convenient way to get the benefits of green tea in a highly concentrated green tea pill form.  This green tea extract is standardized for bioflavonoid-like antioxidants known as polyphenols, particularly Epigallocatechin Gallate (EGCG). EGCG has been found in scientific studies to be a potent antioxidant.

Supplement Facts
Calcium
Green Tea Extract Yielding 35 mg epigallocatechin gallate (EGCG)

Suggested Use: 1 tablet a few times a week with breakfast or lunch. Take green tea extract pill in the morning or midday before or with a meal. Evening use may lead to mild insomnia.

Chlorogenic acid for weight loss
The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.
J Int Med Res. 2007. Thom E. ETC Research and Development, Oslo, Norway.
The results from a clinical study performed in 12 healthy volunteers with different coffee products containing glucose show that instant coffee enriched with chlorogenic acid induced a reduction in the absorption of glucose of 6.9% compared with control. No such effects were seen with normal or decaffeinated instant coffee. In a second, comparative, randomized, double-blind, 12-week study we investigated the effect on the body mass of 30 overweight people, compared with normal instant coffee. The average losses in mass in the chlorogenic acid enriched and normal instant coffee groups were 5.4 and 1.7 kg, respectively. We conclude that chlorogenic acid enriched instant coffee appears to have a significant effect on the absorption and utilization of glucose from the diet. This effect, if the coffee is used for an extended time, may result in reduced body mass and body fat when compared with the use of normal instant coffee.

Chlorogenic acid protects against radiation
Radioprotective effects of chlorogenic acid against mortality induced by g-irradiation in mice.
Methods Find Exp Clin Pharmacol. 2008. Hosseinimehr SJ, Zakaryaee V, Ahmadi A, Akhlaghpoor S. Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
The radioprotective effects of the naturally occurring compound chlorogenic acid have been investigated against mortality induced by gamma-irradiation in mice. Chlorogenic acid was administrated at single doses of 100, 200 and 400 mg/kg 1 or 24 h prior to lethal dose of gamma-irradiation (8.5 Gy). Chlorogenic acid exhibited concentration-dependent activity on 1,1-diphenyl-2-picrylhydrazyl free radical to show strong antioxidant activity. It appeared that chlorogenic acid with antioxidant activity reduced mortality induced by gamma-irradiation.

Chlorogenic acid raw herb and material suppliers
Chlorogenic acid is sold at 20 percent, 30 percent and 98 percent concentration.

Chemistry
Chlorogenic acid is the ester formed between certain trans cinnamic acid and (L)-quinic acid.

Coffee consumption
Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption.
Drug Metab Dispos. 2009. Plant Products and Human Nutrition Group, Division of Environmental and Evolutionary Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK.
Human subjects drank coffee containing 412 mumol of chlorogenic acids, and plasma and urine were collected 0 to 24 h after ingestion and were analyzed by high-performance liquid chromatography-mass spectrometry. Within 1 h, some of the components in the coffee reached nanomole peak plasma concentrations (C(max)), whereas chlorogenic acid metabolites, including caffeic acid-3-O-sulfate and ferulic acid-4-O-sulfate and sulfates of 3- and 4-caffeoylquinic acid lactones, had higher C(max) values. In contrast, dihydroferulic acid, its 4-O-sulfate, and dihydrocaffeic acid-3-O-sulfate exhibited much higher C(max) values (145-385 nM) with T(max) values in excess of 4 h, indicating absorption in the large intestine and the probable involvement of catabolism by colonic bacteria. These three compounds, along with ferulic acid-4-O-sulfate and dihydroferulic acid-4-O-glucuronide, were also major components to be excreted in urine (8.4-37.1 mumol) after coffee intake. Feruloylglycine, which is not detected in plasma, was also a major urinary component. Other compounds, not accumulating in plasma but excreted in smaller quantities, included the 3-O-sulfate and 3-O-glucuronide of isoferulic acid, dihydro(iso)ferulic acid-3-O-glucuronide, and dihydrocaffeic acid-3-O-glucuronide. Overall, the 119.9 mumol excretion of the chlorogenic acid metabolites corresponded to 29% of intake, indicating that as well as being subject to extensive metabolism, chlorogenic acids in coffee are well absorbed. Pathways for the formation of the various metabolites within the body are proposed. Urinary dihydrocaffeic acid-3-O-sulfate and feruloylglycine are potentially very sensitive biomarkers for the consumption of relatively small amounts of coffee.