Gynostemma pentaphyllum herb
Gynostemma pentaphyllum is a plant that grows wild in China, as well
as many other countries throughout Asia. Early research in rodents indicates it
may be used for cholesterol and gastric ulcer prevention. Gynostemma pentaphyllum is a
Chinese herb used in
Chinese Medicine. Gynostemma pentaphyllum contains many compounds, including saponins and
flavones.
Gynostemma pentaphyllum herb, also called
Jiaogulan or Southern Ginseng, is
a popular tonic in Asia. Gynostemma pentaphyllum is an adaptogen,
antioxidant and rejuvenator. It
supports normal cholesterol levels, immune modulation, and healthy metabolism.
Paradise Formulas Jiaogulan, 60
tablets
Botanical Support for Mental and Physical Stamina
Dietary Supplement
Planetary Formulas Full Spectrum Jiaogulan is specially extracted to yield a
broad spectrum of
Gynostemma pentaphyllum constituents.
Gynostemma pentaphyllum originates from Southern
China where much of traditional Chinese herbalism evolved. It has been
traditionally used as a strengthening tonic to increase physical and mental
stamina.
Gynostemma pentaphyllum contains 82 saponins called gypenosides, some of which are
directly related to the ginsenosides found in ginseng root.
Jiaogulan
Supplement Facts:
Calcium 127 mg 15%
Jiaogulan Extract 375 mg +
(Gynostemma pentaphyllum) (Standardized to 10% gypenosides)
+ Daily Value not established
Suggested Use: 1 Gynostemma pentaphyllum tablet a few times a week or as directed by a qualified healthcare professional.
This Gynostemma pentaphyllum supplement is made by
Planetary Formulas
supplement company.
Gynostemma pentaphyllum
for gastric ulcer
prevention
Phytopreventative effects of Gynostemma pentaphyllum against acute
Indomethacin-induced gastrointestinal and renal toxicity in rats.
Phytother Res. 2007 Mar 23; Faculty of Pharmacy and Herbal Medicines
Research and Education Centre (HMREC), A15, University of Sydney, NSW, 2006,
Australia.
In the present study, the phytoprotective effects of
gypenosides from
Gynostemma pentaphyllum throughout the gastrointestinal tract and kidney were
examined in indomethacin-treated rats. Indomethacin induced gastric and
intestinal damage as well as renal toxicity after a single toxicological dose
(10 mg/kg) in rats. Acute oral administration of the gypenoside extract (200
mg/kg) significantly reduced gastric and intestinal toxicity induced by
indomethacin as measured by ulceration, caecal haemoglobin and plasma
haptoglobin. A significant decrease in small intestinal lactose fermenting
enterobacteria was evident in animals treated with indomethacin and those
pre-treated with
Gynostemma pentaphyllum then indomethacin. In the renal system, kidney
toxicity was evident after indomethacin and in animals pre-treated with
indomethacin plus
Jiaogulan
with an increase in urinary N-acetyl-beta-glucosaminidase
and a decrease in urinary sodium and chloride electrolyte output. These studies
demonstrate the efficacy of Gynostemma pentaphyllum
in lowering gastrointestinal damage induced by indomethacin.
Jiaogulan for gastric ulcer
prevention
Anti-hyperlipidemic and hypoglycemic
effects of Gynostemma pentaphyllum in the Zucker fatty rat.
J Pharm Pharm Sci. 2006;9(3):281-91. Faculty of Pharmacy and Herbal
Medicines Research and Education Centre University of Sydney, Building Al5,
Sydney NSW 2006.
Gynostemma pentaphyllum is a traditional Chinese medicine used for a variety of conditions, including
elevated cholesterol. We have examined the pharmacological anti-hyperlipidemic
and hypoglycemic effectiveness of Gynostemma pentaphyllum in the obese Zucker
fatty diabetic rat model. After treatment for 4 days Gynostemma pentaphyllum 250
mg/kg reduced triglyceride (33%), total cholesterol, (13%) and low density
lipoprotein cholesterol levels (33%). These effects were dose-dependent and
maintained for at least 5 weeks. Chronic treatment for 3-5 weeks also reduced
post-prandial hypertriglyceridemia induced by olive oil 10 mg/kg in the Zucker
fatty rats but had no significant effect in lowering sucrose-induced
hyperglycemia in Sprague-Dawley rats. A novel regulation by Gynostemma of
glucose levels was also observed in the Zucker fatty rat model. In a glucose
tolerance test in obese and lean Zucker rats pretreatment with Gynostemma
pentaphyllum 250 mg/kg demonstrated glucose levels were significantly less 2
hours post challenge (20%) in the Gynostemma pentaphyllum obese rats compared to
the control group. Gynostemma pentaphyllum did not significantly reduce glucose
levels at 120 min in the lean strain, in contrast to the 20% decrease seen in
the obese rat. In vitro, Gynostemma pentaphyllum inhibited alpha-glucosidase
activity (50% inhibition at 42.8), which compared to acarbose (50% at 53.9
microg/mL). The improvement in glucose tolerance at 120 min by Gynostemma
pentaphyllum in obese Zucker fatty rats but not lean rats suggests that it may
improve insulin receptor sensitivity and together with the significant reduction
of hypertriglyceridemia, cholesterol and low density lipoprotein cholesterol
suggests that Gynostemma should be examined further by oral hypoglycemic/anti-hyperlipidemic
therapy.
home green tea extract home