Gynostemma pentaphyllum herbal extract health benefit
Gynostemma pentaphyllum is a plant that grows wild in China, as well
as many other countries throughout Asia. Early research in rodents indicates it
may be used for cholesterol and gastric ulcer prevention. Gynostemma pentaphyllum is a
Chinese herb used in
Chinese Medicine. Gynostemma pentaphyllum contains many compounds, including saponins and
flavones.
Gynostemma pentaphyllum herb, also called
Jiaogulan or Southern Ginseng, is
a popular tonic in Asia. Gynostemma pentaphyllum is an adaptogen,
antioxidant and rejuvenator. It
supports normal cholesterol levels, immune modulation, and healthy metabolism.
Paradise Formulas Jiaogulan Gynostemma pentaphyllum, 60
tablets
Botanical Support for Mental and Physical Stamina
Dietary Supplement
Planetary Formulas Full Spectrum Jiaogulan is specially extracted to yield a
broad spectrum of Gynostemma pentaphyllum constituents.
Gynostemma pentaphyllum originates from Southern
China where much of traditional Chinese herbalism evolved. It has been
traditionally used as a strengthening tonic to increase physical and mental
stamina. It contains 82 saponins called gypenosides, some of which are
directly related to the ginsenosides found in ginseng root.
Paradise Formulas Gynostemma pentaphyllum Jiaogulan, 60
tablets

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Supplement Facts:
Calcium 127 mg 15%
Jiaogulan Extract 375 mg
(Gynostemma pentaphyllum) (Standardized to 10% gypenosides)
Suggested Use: 1 Gynostemma pentaphyllum tablet a few times a week or as directed by a qualified healthcare professional.
This Gynostemma pentaphyllum supplement is made by Planetary Formulas supplement company.
Gynostemma pentaphyllum for blood
sugar and diabetes
Potential hypoglycemic effect of an ethanol extract of Gynostemma pentaphyllum
in C57BL/KsJ-db/db mice.
J Med Food. 2008; Department of Food Science and Nutrition, Kyungpook
National University, Daegu, Republic of Korea.
This study was conducted to evaluate the blood sugar lowering effect of an
extract of Gynostemma pentaphyllum Makino, containing standardized
concentrations of gypenosides. Our results suggest that the supplementation of
high-dose Gynostemma pentaphyllum extract (0.01%) in the diet lowers the blood
glucose level by altering the hepatic glucose metabolic enzyme activities.
Gynostemma pentaphyllum for gastric ulcer
prevention
Phytopreventative effects of Gynostemma pentaphyllum against acute
Indomethacin-induced gastrointestinal and renal toxicity in rats.
Phytother Res. 2007; Faculty of Pharmacy and Herbal Medicines
Research and Education Centre (HMREC), University of Sydney, NSW,
Australia.
In the present study, the phytoprotective effects of
gypenosides from
Gynostemma pentaphyllum throughout the gastrointestinal tract and kidney were
examined in indomethacin-treated rats. Indomethacin induced gastric and
intestinal damage as well as renal toxicity after a single toxicological dose
(10 mg/kg) in rats. Acute oral administration of the gypenoside extract (200
mg/kg) significantly reduced gastric and intestinal toxicity induced by
indomethacin as measured by ulceration, caecal haemoglobin and plasma
haptoglobin. A significant decrease in small intestinal lactose fermenting
enterobacteria was evident in animals treated with indomethacin and those
pre-treated with Gynostemma pentaphyllum then indomethacin. In the renal system, kidney
toxicity was evident after indomethacin and in animals pre-treated with
indomethacin plus Jiaogulan with an increase in urinary N-acetyl-beta-glucosaminidase
and a decrease in urinary sodium and chloride electrolyte output. These studies
demonstrate the efficacy of Gynostemma pentaphyllum in lowering gastrointestinal damage induced by indomethacin.
Jiaogulan for gastric ulcer
prevention
Anti-hyperlipidemic and hypoglycemic
effects of Gynostemma pentaphyllum
Jiaogulan in the Zucker fatty rat.
J Pharm Pharm Sci. 2006. Faculty of Pharmacy and Herbal
Medicines Research and Education Centre University of Sydney,
Sydney NSW.
Gynostemma pentaphyllum is a traditional Chinese medicine used for a variety of conditions, including
elevated cholesterol. We have examined the pharmacological anti-hyperlipidemic
and hypoglycemic effectiveness of Gynostemma pentaphyllum in the obese Zucker
fatty diabetic rat model. After treatment for 4 days Gynostemma pentaphyllum 250
mg/kg reduced triglyceride (33%), total cholesterol, (13%) and low density
lipoprotein cholesterol levels (33%). These effects were dose-dependent and
maintained for at least 5 weeks. Chronic treatment for 3-5 weeks also reduced
post-prandial hypertriglyceridemia induced by olive oil 10 mg/kg in the Zucker
fatty rats but had no significant effect in lowering sucrose-induced
hyperglycemia in Sprague-Dawley rats. A novel regulation by Gynostemma of
glucose levels was also observed in the Zucker fatty rat model. In a glucose
tolerance test in obese and lean Zucker rats pretreatment with Gynostemma
pentaphyllum 250 mg/kg demonstrated glucose levels were significantly less 2
hours post challenge (20%) in the Gynostemma pentaphyllum obese rats compared to
the control group. Gynostemma pentaphyllum did not significantly reduce glucose
levels at 120 min in the lean strain, in contrast to the 20% decrease seen in
the obese rat. In vitro, Gynostemma pentaphyllum inhibited alpha-glucosidase
activity (50% inhibition at 42.8), which compared to acarbose (50% at 53.9
microg/mL). The improvement in glucose tolerance at 120 min by Gynostemma
pentaphyllum in obese Zucker fatty rats but not lean rats suggests that it may
improve insulin receptor sensitivity and together with the significant reduction
of hypertriglyceridemia, cholesterol and low density lipoprotein cholesterol
suggests that Gynostemma should be examined further by oral hypoglycemic/anti-hyperlipidemic
therapy.
Liver disease benefit
The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver
disease.
Altern Ther Health Med. 2006. Division of Endocrinology and Metabolism,
Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung
University, Taiwan.
Other than weight reduction by dieting or physical activity, there are no
well-documented medical treatments for fatty liver disease. To
evaluate the efficacy of the add-on Gynostemma pentaphyllum (GP) in research
subjects with nonalcoholic fatty liver disease. A randomized, single-blind,
controlled clinical trial. Fifty-six research subjects who were diagnosed with
nonalcoholic fatty liver by abdominal ultrasound scanning. The treatment group
and the control group followed a controlled diet for 2 months. After 2 months,
the treatment group continued to diet and received 80 mL GP extraction for 4
months; the control group continued to diet and received a placebo capsule for 4
months. After 2 months of dieting, BMI and most biochemistry data decreased in
both study groups. There were no significant differences in BMI or biochemistry
data at month 2 between the 2 study groups. At month 6, BMI, triglyceride,
aspartate aminotransferase (AST), alanine aminotransferase, alkaline phosphatase,
insulin (ALP), insulin resistance index (HOMA-IR), and fatty liver score were
reduced in both groups. The treatment group saw significant reductions in BMI,
AST, ALP, insulin, and HOMA-IR, however. Changes in uric acid levels in the 2
groups from month 2 to month 6 were statistically significant. GP is an
effective adjunct treatment to diet therapy for patients with nonalcoholic fatty
liver disease.
Which is a more potent antioxidant,
green tea extract or Jiaogulan supplement?
We have not seen such comparisons.