Gynostemma pentaphyllum herbal extract health benefit
Gynostemma pentaphyllum is a plant that grows wild in China, as well
as many other countries throughout Asia. Early research in rodents indicates it
may be used for cholesterol and gastric ulcer prevention. Gynostemma pentaphyllum is a
Chinese herb used in
Chinese Medicine. Gynostemma pentaphyllum contains many compounds, including saponins and
Gynostemma pentaphyllum herb, also called Jiaogulan or Southern Ginseng, is a popular tonic in Asia. Gynostemma pentaphyllum is an adaptogen, antioxidant and rejuvenator. It supports normal cholesterol levels, immune modulation, and healthy metabolism.
Paradise Formulas Jiaogulan Gynostemma pentaphyllum, 60
Botanical Support for Mental and Physical Stamina
Planetary Formulas Full Spectrum Jiaogulan is specially extracted to yield a broad spectrum of Gynostemma pentaphyllum constituents. Gynostemma pentaphyllum originates from Southern China where much of traditional Chinese herbalism evolved. It has been traditionally used as a strengthening tonic to increase physical and mental stamina. It contains 82 saponins called gypenosides, some of which are directly related to the ginsenosides found in ginseng root.
Paradise Formulas Gynostemma pentaphyllum Jiaogulan, 60
pentaphyllum on sale
Calcium 127 mg 15%
Jiaogulan Extract 375 mg
(Gynostemma pentaphyllum) (Standardized to 10% gypenosides)
Suggested Use: 1 Gynostemma pentaphyllum tablet a few times a week or as directed by a qualified healthcare professional.
This Gynostemma pentaphyllum supplement is made by Planetary Formulas supplement company.
Gynostemma pentaphyllum for blood
sugar and diabetes
Potential hypoglycemic effect of an ethanol extract of Gynostemma pentaphyllum in C57BL/KsJ-db/db mice.
J Med Food. 2008; Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
This study was conducted to evaluate the blood sugar lowering effect of an extract of Gynostemma pentaphyllum Makino, containing standardized concentrations of gypenosides. Our results suggest that the supplementation of high-dose Gynostemma pentaphyllum extract (0.01%) in the diet lowers the blood glucose level by altering the hepatic glucose metabolic enzyme activities.
Gynostemma pentaphyllum for gastric ulcer prevention
Phytopreventative effects of Gynostemma pentaphyllum against acute Indomethacin-induced gastrointestinal and renal toxicity in rats.
Phytother Res. 2007; Faculty of Pharmacy and Herbal Medicines Research and Education Centre (HMREC), University of Sydney, NSW, Australia.
In the present study, the phytoprotective effects of gypenosides from Gynostemma pentaphyllum throughout the gastrointestinal tract and kidney were examined in indomethacin-treated rats. Indomethacin induced gastric and intestinal damage as well as renal toxicity after a single toxicological dose (10 mg/kg) in rats. Acute oral administration of the gypenoside extract (200 mg/kg) significantly reduced gastric and intestinal toxicity induced by indomethacin as measured by ulceration, caecal haemoglobin and plasma haptoglobin. A significant decrease in small intestinal lactose fermenting enterobacteria was evident in animals treated with indomethacin and those pre-treated with Gynostemma pentaphyllum then indomethacin. In the renal system, kidney toxicity was evident after indomethacin and in animals pre-treated with indomethacin plus Jiaogulan with an increase in urinary N-acetyl-beta-glucosaminidase and a decrease in urinary sodium and chloride electrolyte output. These studies demonstrate the efficacy of Gynostemma pentaphyllum in lowering gastrointestinal damage induced by indomethacin.
Jiaogulan for gastric ulcer
Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum Jiaogulan in the Zucker fatty rat.
J Pharm Pharm Sci. 2006. Faculty of Pharmacy and Herbal Medicines Research and Education Centre University of Sydney, Sydney NSW.
Gynostemma pentaphyllum is a traditional Chinese medicine used for a variety of conditions, including elevated cholesterol. We have examined the pharmacological anti-hyperlipidemic and hypoglycemic effectiveness of Gynostemma pentaphyllum in the obese Zucker fatty diabetic rat model. After treatment for 4 days Gynostemma pentaphyllum 250 mg/kg reduced triglyceride (33%), total cholesterol, (13%) and low density lipoprotein cholesterol levels (33%). These effects were dose-dependent and maintained for at least 5 weeks. Chronic treatment for 3-5 weeks also reduced post-prandial hypertriglyceridemia induced by olive oil 10 mg/kg in the Zucker fatty rats but had no significant effect in lowering sucrose-induced hyperglycemia in Sprague-Dawley rats. A novel regulation by Gynostemma of glucose levels was also observed in the Zucker fatty rat model. In a glucose tolerance test in obese and lean Zucker rats pretreatment with Gynostemma pentaphyllum 250 mg/kg demonstrated glucose levels were significantly less 2 hours post challenge (20%) in the Gynostemma pentaphyllum obese rats compared to the control group. Gynostemma pentaphyllum did not significantly reduce glucose levels at 120 min in the lean strain, in contrast to the 20% decrease seen in the obese rat. In vitro, Gynostemma pentaphyllum inhibited alpha-glucosidase activity (50% inhibition at 42.8), which compared to acarbose (50% at 53.9 microg/mL). The improvement in glucose tolerance at 120 min by Gynostemma pentaphyllum in obese Zucker fatty rats but not lean rats suggests that it may improve insulin receptor sensitivity and together with the significant reduction of hypertriglyceridemia, cholesterol and low density lipoprotein cholesterol suggests that Gynostemma should be examined further by oral hypoglycemic/anti-hyperlipidemic therapy.
Liver disease benefit
The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease.
Altern Ther Health Med. 2006. Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taiwan.
Other than weight reduction by dieting or physical activity, there are no well-documented medical treatments for fatty liver disease. To evaluate the efficacy of the add-on Gynostemma pentaphyllum (GP) in research subjects with nonalcoholic fatty liver disease. A randomized, single-blind, controlled clinical trial. Fifty-six research subjects who were diagnosed with nonalcoholic fatty liver by abdominal ultrasound scanning. The treatment group and the control group followed a controlled diet for 2 months. After 2 months, the treatment group continued to diet and received 80 mL GP extraction for 4 months; the control group continued to diet and received a placebo capsule for 4 months. After 2 months of dieting, BMI and most biochemistry data decreased in both study groups. There were no significant differences in BMI or biochemistry data at month 2 between the 2 study groups. At month 6, BMI, triglyceride, aspartate aminotransferase (AST), alanine aminotransferase, alkaline phosphatase, insulin (ALP), insulin resistance index (HOMA-IR), and fatty liver score were reduced in both groups. The treatment group saw significant reductions in BMI, AST, ALP, insulin, and HOMA-IR, however. Changes in uric acid levels in the 2 groups from month 2 to month 6 were statistically significant. GP is an effective adjunct treatment to diet therapy for patients with nonalcoholic fatty liver disease.
Which is a more potent antioxidant,
green tea extract or Jiaogulan supplement?
We have not seen such comparisons.